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William Shingler Selected Research

TroVax (5T4 cancer vaccine)

11/2010Cross-trial analysis of immunologic and clinical data resulting from phase I and II trials of MVA-5T4 (TroVax) in colorectal, renal, and prostate cancer patients.
9/2009Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): a phase 2 trial.
5/2009Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-alpha.
11/2008Vaccination of renal cell cancer patients with modified vaccinia ankara delivering tumor antigen 5T4 (TroVax) administered with interleukin 2: a phase II trial.
7/2008Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses.
8/2007Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses.

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William Shingler Research Topics

Disease

5Vaccinia
09/2009 - 08/2007
3Renal Cell Carcinoma (Grawitz Tumor)
09/2009 - 11/2008
2Neoplasms (Cancer)
11/2010 - 05/2009
2Colorectal Neoplasms (Colorectal Cancer)
07/2008 - 08/2007
1Prostatic Neoplasms (Prostate Cancer)
11/2010
1Kidney Neoplasms (Kidney Cancer)
05/2009

Drug/Important Bio-Agent (IBA)

6TroVax (5T4 cancer vaccine)IBA
11/2010 - 08/2007
6Neoplasm Antigens (Tumor Antigens)IBA
11/2010 - 08/2007
2Interferon-alpha (Interferon Alfa)IBA
09/2009 - 05/2009
2VaccinesIBA
09/2009 - 11/2008
1Membrane Glycoproteins (Membrane Glycoprotein)IBA
11/2010
1AntibodiesIBA
11/2010
1thiamine triphosphorate (TTP)IBA
05/2009
1AntigensIBA
05/2009
1Interleukin-2 (IL2)IBA
11/2008
1Fluorouracil (Carac)FDA LinkGeneric
07/2008
1Leucovorin (Folinic Acid)FDA Link
07/2008
1Irinotecan (Camptosar)FDA LinkGeneric
07/2008

Therapy/Procedure

2Drug Therapy (Chemotherapy)
07/2008 - 08/2007
1Aftercare (After-Treatment)
11/2010